Urticaria pigmentosa
Urticaria pigmentosa ndiyo inonyanya kuzivikanwa seyakanyanya kuoneka mu mastocytosis. Chirwere chisiri kazhinji chinokonzerwa nekuwanda kwemast cells muganda anoburitsa mikoko kana maronda paganda kana akatsamwa. Mavara matsvuku kana mashava anowanzoonekwa paganda, kazhinji pachipfuva, humu, uye kumashure. Aya mast masero, kana akatsamwa (semuenzaniso nekukwesha ganda, kuratidzwa kwekupisa), anoburitsa histamine yakawandisa, zvichikonzera allergic reaction inotungamira kumikoko inogara munzvimbo yekushatirwa, dzimwe nguva inonzi “Darier's sign”.
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ReferencesMastocytosis imamiriro ekuti kune kuwanda kwemasero mast, anowanzo kuwanikwa munzvimbo dzakasiyana dzemuviri sekuganda, mwongo, uye hurongwa hwekugaya chikafu. Maererano neWorld Health Organisation (WHO), cutaneous mastocytosis inogona kupatsanurwa kuita mhando nhatu huru. Rudzi rwekutanga (mastocytomas) runosanganisira maronda ega kana mashoma (≤3). Rudzi rwechipiri (urticaria pigmentosa) runosanganisira maronda mazhinji, anowanzo kubva paanopfuura gumi kusvika pasi pezana. Rudzi rwechitatu runoratidza kupararira kwakanyanya mukati meganda. Urticaria pigmentosa ndiyo inowanzozivikanwa se cutaneous mastocytosis muvana, asi inogona kuitikawo kuvanhu vakuru. Kazhinji idambudziko risingakuvadzi rinowanikwa panguva yekuyaruka. Kusiyana ne mastocytosis yevakuru, urticaria pigmentosa inokonzeresa zvishoma kukanganisa nhengo dzomukati. Chimiro chimwe chakasiyana che urticaria pigmentosa ndicho chikonzero chekuvheneka, kuvava, kutsvuka‑kutsvukuruka, kana makwapa ebrown kana maronda paganda, anozivikanwa semikoko. Aya mavara anowanzoonekwa muhuduku uye anogona kuramba aripo kweupenyu hwese.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mumwe musikana ane makore 6 ekukura akauya aine mavara akati wandei matema akatanga kubuda mumusoro make achibva apararira kumeso nemuviri mumwedzi mitanhatu yapfuura. Akataura nezvekunzwa kusimuka, kutsvuka, uye kurwadziwa kana paine pressure. Haana kusangana nekuputika, kurutsa, manyoka, kana kufema, uye nhoroondo yake yezvehutano nemhuri haina kupa mazano akakodzera. Pakuuongorora, takawana mavara akasviba akati wandei pamusoro wake, pahuma, kumeso, uye mutsipa, pamwe chete nematima akasimudzwa zvishoma pachipfuva nekumusana. Kukwesha makwapa zvishoma kwakakonzera kuzvimba nekukwenya mukati memaminitsi maviri, asi zviratidzo zvakapera mukati memaminitsi gumi nemashanu kusvika makumi maviri (Darier's sign).
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
